I've been running a Blue Rose game for about 2 years now. I guess that makes it the longest running game I've run.
So far, I've had the PC's on standard envoy missions. The first couple of adventures were the Harmony story from the main book, and the quickstart adventure about a ghost-mom. There is a long running plot revolving around a young woman who is probably the daughter of the moon goddess Selene, and some darkfiends who are indistinguishable from humans until killed. But those are on hold for now.
The current adventure deals with the Jarzoni. They've invented airships, and have invaded Aldis. Right now they control the area directly west of the Veran Marsh, and the front line is concentrated on the river where Kella's Ford is. (I've named it the Iifa River for reference.)
The PC's are on the west half of Kella's Ford, and the Jarzoni have occupied the east half. Our heroes made daring raids with the help of the local sea-folk (river-folk, really), and rescued many arcanists who were to be burned at the stake. While engaged in the raids, our heroes were nearly foiled by psychic Colonel Gair, who is unique among the Jarzoni military officers in that he is a rhy-cat.
The PC's also managed to make friends with a group of local ghosts, who don't like the idea of their town being invaded. Haunting and pranks ensued.
"okay, I'm going to get closer to the skeletons and attack them, since I assume they are evil, because they are f***ing undead blokes, and undead blokes are evil"
-Jorjowsky's wife, playing the quickstart